Wayel Abdulahad
Wayel Abdulahad
The principle objective of our research is to investigate the phenotype and function of pathogenic B-cells and T-cells in patients with systemic autoimmune diseases, in particular ANCA-associated vasculitides, Systemic Lupus Erythematosus, Sjögren’s syndrome, Ankylosing spondylitis, and Giant Cell Arteritis. We aim to gain a better understanding of the disease mechanisms in order to identify disease-specific biomarkers and targets for therapeutic intervention.
Affiliation
Dept of Rheumatology & Clinical Immunology/ Dept of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands
w.abdulahad@umcg.nl
Publications
Land J, Lintermans LL, Stegeman CA, Muñoz-Elías EJ, Tarcha EJ, Iadonato SP,Heeringa P, Rutgers A, Abdulahad WH. Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis. Front Immunol. 2017 Sep 26;8:1205. doi: 10.3389/fimmu.2017.01205.
van der Geest KS, Lorencetti PG, Abdulahad WH, Horst G, Huitema M, Roozendaal C, Kroesen BJ, Brouwer E, Boots AM. Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors. Exp Gerontol. 2016 Mar;75:24-9. doi: 10.1016/j.exger.2015.12.009.
Lepse N, Land J, Rutgers A, Kallenberg CG, Stegeman CA, Abdulahad WH, Heeringa P. Toll-like receptor 9 activation enhances B cell activating factor and interleukin-21 induced anti-proteinase 3 autoantibody production in vitro. Rheumatology (Oxford). 2016 Jan;55(1):162-72. doi: 10.1093/rheumatology/kev293.
Land J, Abdulahad WH, Sanders JS, Stegeman CA, Heeringa P, Rutgers A. Regulatory and effector B cell cytokine production in patients with relapsing granulomatosis with polyangiitis. Arthritis Res Ther. 2016 Apr 4;18:84. doi: 10.1186/s13075-016-0978-1.
van der Geest KS, Abdulahad WH, Chalan P, Rutgers A, Horst G, Huitema MG, Roffel MP, Roozendaal C, Kluin PM, Bos NA, Boots AM, Brouwer E. Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica. Arthritis Rheumatol. 2014 Jul;66(7):1927-38. doi: 10.1002/art.38625.
Theses
N. Lepse: The regulatory and effector functions of B cells in ANCA-associated vasculitis. Awarded: 2014
J. Land: B cell phenotype and function in granulomatosis with polyangiitis: Towards prediction of relapse. Awarded: 2016
Current PhD projects
A. von Borstel: B cells in small vessel vasculitis: towards balance between regulators and effectors
G.J. Dekkema: miRNAs in ANCA associated vasculitis; regulators of aberrant T and B cell function?
