Lisa van Baarsen
Over the past years I gained extensive experience in translational research focused on personalized medicine, biomarker discovery and lymph node immunobiology. By combining my genomics and immunology expertise with unique patient cohort tissue samples my ultimate goal is to unravel the molecular and biological processes leading to systemic autoimmune diseases and to develop innovative preventive strategies. By studying unique human lymphoid and synovial tissue biopsies obtained during the pre-clinical and earliest phases of rheumatoid arthritis, it is my ambition to lay the foundation for the development of novel therapies to prevent and treat this chronic disabling immune-mediated autoimmune disease.
Amsterdam Rheumatology and immunology Center (ARC), Department of Clinical Immunology & Rheumatology Center and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands
J.S. Hähnlein, R. Nadafi, T. de Jong, T.H. Ramwadhdoebe, J.F. Semmelink, K.I. Maijer, IJ.A. Zijlstra, M. Maas, D.M. Gerlag, T.B.H. Geijtenbeek, et.al. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis. Arthritis Res Ther. 2018 (accepted for publication)
Ramwadhdoebe TH, Hahnlein J, Maijer KI, van Boven LJ, Gerlag DM, Tak PP, van Baarsen LG. Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis. Eur J Immunol. 2016
Ramwadhdoebe TH, Hahnlein J, van Kuijk BJ, Choi IY, van Boven LJ, Gerlag DM, Tak PP, van Baarsen LG. Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity. Clin Transl Immunology. 2016.
van Baarsen LG, de Hair MJ, Ramwadhdoebe TH, Zijlstra IJ, Maas M, Gerlag DM, Tak PP. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis. Ann Rheum Dis. 2013.
Gerlag DM, Raza K, van Baarsen LG, Brouwer E, Buckley CD, Burmester GR, Gabay C, Catrina AI, Cope AP, Cornelis F, et al. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis. 2012.
M.J.H. de Hair: Clinical studies and tissues analyses in the earliest phases of rheumatoid arthritis: in search of the transition from being at risk to having clinically apparent disease. Awarded: 2013 (AMC/UvA)
Current PhD projects
Tamara Ramwadhdoebe: Immunoregulation by lymph node T cells during the earliest phases of rheumatoid arthritis
Janine Hähnlein: Immunoregulation by human lymph node stromal cells during health and autoimmunity
Reza Nadafi (VUMC; Prof. dr. Reina Mebius): Study the immunomodulatory effect of lymph node stromal cells in rheumatic disease