Skin can be the target organ of B-cell mediated autoimmune disease and also the primary site of B-cell lymphomagenesis. B-cell lymphomas tat Primary cutaneous B-cell lymphomas (CBCL) a heterogeneous group of lymphomas that primary originate in skin. Studies from our group, and others, characterized three groups of CBCL including primary cutaneous marginal zone B-cell lymphomas, primary cutaneous follicle centre lymphomas and primary cutaneous lymphomas, leg type, that have now been incorporated in the WHO classification of tumours of haematopoietic and lymphoid tissues. We initiated international collaborative studies that have resulted in recommended staging procedures and consensus treatment recommendations for different CBCL subtypes. The progress in CBCL classification has enabled molecular studies on well-defined groups of patients. Recent studies are aimed at translating insight from these molecular studies in CBCL into clinical care including the identification of targets amenable for therapeutic targeting. Recently we started a specialized clinic for immunobullous diseases that runs in close liaison with the specialised diagnostic laboratory at the dermatology department in Groningen.
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
Koens L, Zoutman WH, Ngarmlertsirichai P, Przybylski GK, Grabarczyk P, Vermeer MH, Willemze R, Jansen PM, Schmidt CA, Tensen CP. Nuclear factor-kappaB pathway-activating gene aberrancies in primary cutaneous large B-cell lymphoma, leg type. J Invest Dermatol. 2014.
Senff NJ, Noordijk EM, Kim YH, Bagot M, Berti E, Cerroni L, Dummer R, Duvic M, Hoppe RT, Pimpinelli N, et al. European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood. 2008.
Dijkman R, Tensen CP, Jordanova ES, Knijnenburg J, Hoefnagel JJ, Mulder AA, Rosenberg C, Raap AK, Willemze R, Szuhai K, et al. Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma. J Clin Oncol. 2006.
Dijkman R, Tensen CP, Buettner M, Niedobitek G, Willemze R, Vermeer MH. Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID. Blood. 2006.
Hoefnagel JJ, Dijkman R, Basso K, Jansen PM, Hallermann C, Willemze R, Tensen CP, Vermeer MH. Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling. Blood. 2005.
Lianne Koens: Clinicopathologic and genetic aspects of primary cutaneous large B-cell lymphomas. Awarded: 2014
Nancy Senff: Cutaneous B-cell lymphoma classification, prognostic factors and management recommendations. Awarded: 2009
Juliette Hoefnagel: Clinicopathologic and genetic features of primary cutaneous B-cell Lymphoma. Awarded: 2007
Current PhD projects
Anne-Roos Schrader: Molecular studies in primary Cutaneous B-cell Lymphoma